Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Vincent Chau1
Tatiana Gladysheva1
Date of Patent
July 27, 2010
1Patent Application Number
116389791
Date Filed
December 14, 2006
1Patent Primary Examiner
Patent abstract
The invention relates to covalent modification of proteins through their conjugation with other proteins. More particularly, the invention relates to the modulation of such conjugation involving the protein NEDD8. The invention provides compositions and methods for detecting and/or modulating the activation and/or conjugation of NEDD8, as well as compositions and methods for discovering molecules which are useful in detecting and/or modulating the activation and/or conjugation of NEDD8. The present invention arises from the purification and charactization of novel NEDD8 activating and conjugating enzymes.
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