Patent 7744914 was granted and assigned to Regents of the University of California on June, 2010 by the United States Patent and Trademark Office.
Vascular smooth muscle cells (VSMCs) adhere to and orient along micropatterned grooves having a depth of 1 to 10 μm and a width of 1 to 20 μm that are imposed on the surface of a vascular implant device. The VSMCs maintain an elongated morphology and reduced proliferation resulting in a decrease in occurrence of intimal hyperplasia upon device implantation.