Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Roger J. Pomerantz0
Gary D. Kao0
Giuseppe Nunnari0
Rene Daniel0
Anna Marie Skalka0
Date of Patent
June 15, 2010
0Patent Application Number
110936920
Date Filed
March 30, 2005
0Patent Primary Examiner
Patent abstract
Cellular targets for anti-retroviral drug development are disclosed. The cellular targets comprise ATR kinase and its relevant substrates, based on the identification of the ATR kinase as required for the final step of retroviral DNA integration. Assays for identifying modulators of retroviral integration via the ATR kinase pathway are disclosed, as well as modulators identified by such assays. Pharmaceutical preparations and methods of their use in treating retroviral infection are also disclosed.
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