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US Patent 7735485 Dry powder inhalation system for transpulmonary administration

Patent 7735485 was granted and assigned to Otsuka Pharmaceutical on June, 2010 by the United States Patent and Trademark Office.

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Current Assignee
Otsuka Pharmaceutical
Otsuka Pharmaceutical
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
Patent Number
7735485
Date of Patent
June 15, 2010
Patent Application Number
10538837
Date Filed
December 12, 2003
Patent Primary Examiner
‌
Johann R. Richter
Patent abstract

A dry powder inhalation system suitable for transpulmonary administration. The dry powder inhalation system is characterized by using a combination of:(1) a vessel housing a freeze-dried composition prepared by freeze-drying a composition liquid containing ingredients in a non-dissolved form, and has:(i) a non-powder cake-like form,(ii) a disintegration index of 0.05 or more, and(iii) a property of becoming fine particles having a mean particle diameter (mass median aerodynamic diameter) of 10 microns or less or a fine particle fraction of 10% or more upon receipt of an air impact having an air speed of at least 1 m/sec and an air flow rate of at least 17 ml/sec; and(2) a device comprising a member capable of applying the air impact to the freeze-dried composition in said vessel, and a member for discharging the powder-form freeze-dried composition that has been made into fine particles.

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