Patent 7732476 was granted and assigned to University of South Florida on June, 2010 by the United States Patent and Trademark Office.
A method of inducing high anti-leukemia activity responsive to the combination of hydroxamic acid analogue histone deacetylase inhibitors and PKC412 against human acute leukemia characterized as expressing phosphorylated (p)FLT3 kinase by a novel flow cytometry-based assay.