Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
W. H. Irwin McLean0
Frances J. D. Smith0
Robyn P. Hickerson0
Roger L. Kaspar0
Date of Patent
May 25, 2010
0Patent Application Number
115105030
Date Filed
August 24, 2006
0Patent Primary Examiner
Patent abstract
A method for treating pachyonychia congenita (PC) by identifying a genetic mutation contributing to PC, preparing a siRNA sequence that inhibits expression of the identified mutation, and administering the siRNA to a cell of a subject afflicted with PC. The siRNA treatment can include silencing of both the mutated and associated wildtype genes for a specific keratin. Specific mutations and inhibitory sequences are identified.
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