Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Michael P. Graziano0
Maureen Laverty0
Xiaorui Yao0
Scott W. Altmann0
Duane A. Burnett0
Harry R. Davis, Jr.0
Date of Patent
May 25, 2010
0Patent Application Number
115863030
Date Filed
October 25, 2006
0Patent Primary Examiner
Patent abstract
The use of azetidinone compounds that are inhibitors of cholesterol absorption as tools for discovering and characterizing proteins involved in trafficking or absorption of cholesterol and/or cholesteryl esters in biological systems is presented. These compounds can serve as tools for competitive binding assays to discover and characterize other chemical agents useful as cholesterol absorption inhibitors. New compounds of the present invention are also highly efficacious inhibitors of cholesterol absorption.
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