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US Patent 7718058 Chromatography column with pack, unpack, and clean-in-place features

Patent 7718058 was granted and assigned to Bio-Rad Laboratories on May, 2010 by the United States Patent and Trademark Office.

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Patent
Patent
1

Patent attributes

Current Assignee
Bio-Rad Laboratories
Bio-Rad Laboratories
1
Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
77180581
Patent Inventor Names
Maurice Agee1
Sebastien Magnaud1
Sebastien Lefebvre1
Philippe Vernot1
Date of Patent
May 18, 2010
1
Patent Application Number
121079161
Date Filed
April 23, 2008
1
Patent Citations Received
‌
US Patent 11745119 Chromatography and synthesis column apparatus and method of assembly
Patent Primary Examiner
‌
Ernest G. Therkorn
1
Patent abstract

A preparative chromatography column is equipped with one or more valves that can each be used to both inject a column packing into the column or withdraw used packing from the column, in addition to cleaning the supply and discharge lines associated with the valve itself, all by moving a movable plug within the valve body and all without protruding into the column interior. Each valve is mounted on the lateral wall of the column just above the filter plate at the column floor, and the plug is movable between a closed position in which the end surface of the plug is flush with the inner wall of the column and an open position in which the plug is recessed within the bore. Each valve has two additional ports in its valve body, positioned such that when the plug is closed, both ports are open to the valve bore, and when the plug is open, at least one of the ports is open to the bore. The position of the plug within the valve bore determines the valve function.

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