Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Philip M. Sass0
Kenneth W. Kinzler0
Luigi Grasso0
Nicholas C. Nicolaides0
Bert Vogelstein0
Date of Patent
April 27, 2010
Patent Application Number
11128420
Date Filed
May 13, 2005
Patent Primary Examiner
Patent abstract
Blockade of mismatch repair in a plant can lead to hypermutation and a new genotype and/or phenotype. One approach used to generate hypermutable plants is through the expression of dominant negative alleles of mismatch repair genes in transgenic plants or derived cells. By introducing these genes into cells and transgenic plants, new cell lines and plant varieties with novel and useful properties can be prepared more efficiently than by relying on the natural rate of mutation. Moreover, methods to inhibit the expression and activity of endogenous plant MMR genes and their encoded products are also useful to generate hypermutable plants.
Timeline
No Timeline data yet.
Further Resources
No Further Resources data yet.
