Patent 7696198 was granted and assigned to Memory Pharmaceuticals on April, 2010 by the United States Patent and Trademark Office.
Selective PDE4 inhibition is achieved by 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds like rolipram and show selectivity with regard to inhibition of other classes of PDEs. The compounds of the present invention are of formula I: