US Patent 7691907 Methods and composition based on discovery of metabolism of nitroglycerin

Patent 7691907 was granted and assigned to Duke University on April, 2010 by the United States Patent and Trademark Office.

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Patent

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Current Assignee

Duke University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

76919070

Patent Inventor Names

Zhiqiang Chen0

Jonathan S. Stamler0

Date of Patent

April 6, 2010

Patent Application Number

105089570

Date Filed

February 24, 2003

Patent Primary Examiner

‌

Frederick Krass

Patent abstract

Therapies are for treating patients in need of nitroglycerin therapy and allow increased dosage, postponement of tolerance and preconditioning, without exacerbating or causing hypotension. Methods for determining cross-tolerance, nitroglycerin effectiveness and dose are also disclosed. Composition for intravenous administration of nitroglycerin does not contain ethanol or contains less ethanol than conventional compositions.

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