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US Patent 7687282 Detection of transmembrane potentials by optical methods

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Patent
Patent
1

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
76872821
Patent Inventor Names
Jesus E. Gonzalez, III1
Roger Y. Tsien1
Date of Patent
March 30, 2010
1
Patent Application Number
115298381
Date Filed
September 29, 2006
1
Patent Citations Received
‌
US Patent 11834551 Photoactive macromolecules and uses thereof
2
‌
US Patent 12018117 Polymer dye modification and applications
3
Patent Primary Examiner
‌
Shafiqul Haq
1
Patent abstract

Methods and compositions are provided for determining the potential of a membrane. In one aspect, the method comprises:(a) introducing a first reagent comprising a hydrophobic fluorescent ion capable of redistributing from a first face of the membrane to a second face of the membrane in response to changes in the potential of the membrane, as described by the Nernst equation,(b) introducing a second reagent which labels the first face or the second face of the membrane, which second reagent comprises a chromophore capable of undergoing energy transfer by either (i) donating excited state energy to the fluorescent ion, or (ii) accepting excited state energy from the fluorescent ion,(c) exposing the membrane to radiation;(d) measuring energy transfer between the fluorescent ion and the second reagent, and(e) relating the energy transfer to the membrane potential.

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