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US Patent 7683170 Methods for preparing Irinotecan

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Patent
Patent
1

Patent attributes

Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
1
Patent Number
76831701
Patent Inventor Names
Friedrich Wissmann1
Silvia Werner1
Holger Rauter1
Date of Patent
March 23, 2010
1
Patent Application Number
116089461
Date Filed
December 11, 2006
1
Patent Primary Examiner
‌
Janet L. Andres
1
Patent abstract

Methods for manufacturing 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin are described comprisingI. reacting a mixture of 1-chlorocarbonyl-4-piperidinopiperidine hydrochloride and 7-ethyl-10-hydroxycamptothecin in a polar aprotic solvent with a base in the presence of catalytic amounts of a N-containing cyclic organic compound having 3 to 20 carbon atoms and optionally in the presence of a water binding agent in an amount which effectively binds any water present in the above reactants and solvents; orII. reacting:(a) 7-Ethyl-10-hydroxycamptothecin in a polar aprotic solvent with phosgene, trichlormethyl-chloroformate, bis(trichloromethyl)carbonate or a alternative to phosgene and a base in the presence of catalytic amounts of a N-containing cyclic organic compound having 3 to 20 carbon atoms; and(b) subsequently with piperidinopiperidine and an amine base.

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