Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Stephanie Ronning0
Michael Ratka0
Rainer Muller0
Stephan Glaser0
Bernhard Rexer0
Claudia Giessel0
Claus Schneider0
Frank Geipel0
...
Date of Patent
February 23, 2010
0Patent Application Number
118534830
Date Filed
September 11, 2007
0Patent Primary Examiner
Patent abstract
The present invention concerns a method for producing recombinant trypsin from porcine pancreas in Pichia pastoris which is soluble and secreted into the culture medium, whereby expression at pH 3.0-4.0 substantially prevents activation of trypsinogen to β-trypsin and autolysis of β-trypsin by α-trypsin into ε-trypsin and from there into inactive peptides.
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