Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Edwin K. Joe0
Richard Rox Anderson0
Bernhard Ortel0
Date of Patent
February 9, 2010
0Patent Application Number
107091220
Date Filed
April 14, 2004
0Patent Primary Examiner
Patent abstract
Methods for preventing damage to the epidermis during PDT induced using a pre-photosensitizing agent are provided. The methods of the present invention utilize spatial confinement to control formation of a photoactive species from a topically-applied pre-photosensitizing agent. In one embodiment, thermal inhibition is used to prevent the metabolism of a pre-photosensitizing agent in epithelial tissue surrounding a treatment site. In another embodiment, a chemical inhibitor can be applied to the epithelial tissue to inhibit the conversion of a pre-photosensitizing agent into a phototoxic species.
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