US Patent 7642356 Process for preparing beta-ketoester compounds

Patent 7642356 was granted and assigned to LG on January, 2010 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7642356

Date of Patent

January 5, 2010

Patent Application Number

12065752

Date Filed

September 15, 2006

Patent Primary Examiner

‌

Janet L. Andres

Patent abstract

The present invention relates to a process for preparing a beta-keto ester compound of formula (1), which is an intermediate for the synthesis of quinolone antibiotics. Particularly, the present invention is characterized by the reaction of an organo nitrile compound with a salt of mono-alkyl malonate in the presence of metal salt, and so the reaction is easy to control due to its endothermic nature, and is devoid of lachrymatory reagents with excellent reproducibility. Subsequent in situ hydrolysis in the presence of aqueous acid solution provided the compound of formula (1).