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US Patent 7634126 Blood and cell analysis using an imaging flow cytometer

Patent 7634126 was granted and assigned to Amnis Corporation on December, 2009 by the United States Patent and Trademark Office.

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Patent
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Current Assignee
Amnis Corporation
Amnis Corporation
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
76341260
Patent Inventor Names
David A. Basiji0
Philip Morrissey0
David Perry0
William E. Ortyn0
Thaddeus George0
Brian Hall0
Cathleen Zimmerman0
Date of Patent
December 15, 2009
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Patent Application Number
123621700
Date Filed
January 29, 2009
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Patent Primary Examiner
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Andrew W Johns
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Patent abstract

Multimodal/multispectral images of a population of cells are simultaneously collected. Photometric and/or morphometric features identifiable in the images are used to separate the population of cells into a plurality of subpopulations. Where the population of cells includes diseased cells and healthy cells, the images can be separated into a healthy subpopulation, and a diseased subpopulation. Where the population of cells does not include diseased cells, one or more ratios of different cell types in patients not having a disease condition can be compared to the corresponding ratios in patients having the disease condition, enabling the disease condition to be detected. For example, blood cells can be separated into different types based on their images, and an increase in the number of lymphocytes, a phenomenon associated with chronic lymphocytic leukemia, can readily be detected.

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