US Patent 7632816 Treatment of Alzheimer amyloid deposition

The present invention is directed to a method of preventing or treating Alzheimer's Disease or of inhibiting accumulation of amyloid-β deposits in a subject by administering to the subject an agent which inhibits interaction between amyloid-β and proteins which chaperone amyloid-β under conditions effective to prevent or treat Alzheimer's Disease in the subject or to inhibit accumulation of amyloid-β deposits in the subject's brain, respectively. Another embodiment of the present invention relates to a method of inhibiting interaction between apolipoprotein E and amyloid-β by administering an agent which blocks interaction of apolipoprotein E and amyloid-β under conditions effect to block such interaction.