A padded X-ray film cassette cover is disclosed for use during an X-ray procedure. The padded cassette cover has a base member and a padded pocket member forming a cassette cavity there between. An X-ray film cassette is inserted within the cassette cavity prior to positioning the film cassette with respect to a patient. The padded cassette cover has a top handle and a side handle formed therewith to facilitate positioning of the cover and cassette assembly. The padded cassette cover is preferably fabricated from materials that facilitate cleaning and sanitization to prevent the transfer of germs, bacteria and infectious materials.