Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Martine Petronella Bos0
Jan Poolman0
Johannes Petrus Maria Tommassen0
Boris Tefsen0
Date of Patent
December 8, 2009
0Patent Application Number
105843620
Date Filed
December 21, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
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