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US Patent 7622491 Modulators of PPAR and methods of their preparation

Patent 7622491 was granted and assigned to Metabolex on November, 2009 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee
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Metabolex
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
76224910
Patent Inventor Names
Zuchun Zhao0
Peng Cheng0
Vera A. Rakhmanova0
Yan Zhu0
Francine M. Gregoire0
Jingyuan Ma0
Date of Patent
November 24, 2009
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Patent Application Number
112029630
Date Filed
August 11, 2005
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Patent Primary Examiner
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Golam M. M. Shameem
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Patent abstract

The present invention is directed to certain novel compounds represented by Formula (I) and pharmaceutically acceptable salts, solvates, hydrates and prodrugs thereof. The present invention is also directed to methods of making and using such compounds and pharmaceutical compositions containing such compounds to treat or control a number of diseases mediated by PPAR such as glucose metabolism, lipid metabolism and insulin secretion, specifically Type 2 diabetes, hyperinsulinemia, hyperlipidemia, hyperuricemia, hypercholesteremia, atherosclerosis, one or more risk factors for cardiovascular disease, Syndrome X, hypertriglyceridemia, hyperglycemia, obesity and eating disorders.

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