Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Tim Jones0
Graham Carter0
John Watkins0
Matthew Baker0
Francis J. Carr0
Date of Patent
November 10, 2009
0Patent Application Number
120771200
Date Filed
March 17, 2008
0Patent Primary Examiner
Patent abstract
The present invention relates a modified human interferon beta (INFβ) which is less immunogenic than human INFβ (SEQ ID NO: 1) when administered in vivo to a human. The modified human INFβ comprises an amino acid residue sequence that differs from SEQ ID NO: 1 by an amino acid residue substitution selected from the group consisting of L57A, L57C, L57D L57E, L57G, L57H, L57K, L57N, L57P, L57Q, L57R, L57S, and L57T and an additional substitution selected from the group consisting of the H140A, H140C, H140G, and H140P.
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