Patent 7615353 was granted and assigned to AVEO Pharmaceuticals on November, 2009 by the United States Patent and Trademark Office.
A diagnostic method for predicting quantitatively whether a human tumor will be responsive or resistant (non-responsive) to treatment with the VEGF inhibitor, tivozanib (AV-951), is disclosed. The test is based on application of an algorithm to measurements of expression levels of the genes in a predictive gene set.