Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Jean Chia-Chun Chang0
Steven R. Leong0
Alexandra L. L. Lazetic0
Juha Punnonen0
Date of Patent
November 3, 2009
0Patent Application Number
113320370
Date Filed
January 13, 2006
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The invention provides polynucleotides and polypeptides encoded therefrom having advantageous properties, including an ability of the polypeptides to preferentially bind a CD28 or CTLA-4 receptor at a level greater or less than the ability of human B7-1 to bind CD28 or CTLA-4, or to induce or inhibit altered level of T cell proliferation response greater compared to that generated by human B7-1. The polypeptides and polynucleotides of the invention are useful in therapeutic and prophylactic treatment methods, gene therapy applications, and vaccines.
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