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US Patent 7608613 Analogs of benzoquinone-containing ansamycins and methods of use thereof

Patent 7608613 was granted and assigned to Infinity Pharmaceuticals on October, 2009 by the United States Patent and Trademark Office.

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Patent

Patent attributes

Current Assignee

Infinity Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7608613

Patent Inventor Names

James R. Porter0

Louis Grenier0

Julian Adams0

Yun Gao0

Roger H. Pak0

Asimina T. Georges Evangelinos0

James L. Wright0

Date of Patent

October 27, 2009

Patent Application Number

12199211

Date Filed

August 27, 2008

Patent Primary Examiner

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Bruck Kifle

Patent abstract

The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.

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