The present invention is directed to a mixing unit comprising a sealed container joined to a second container. When the second container is fully united with the sealed container, a seal in the sealed container is breached and the contents of the first container and the second container can be mixed. The seal is breached by a bushing enclosed within the sealed container or enclosed in a coupler between the sealed container and the second container which is advanced against the seal, and ruptures the seal when the second container is advanced into the coupler of the coupler portion of the sealed container.