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US Patent 7601499 Paired end sequencing

Patent 7601499 was granted and assigned to 454 Life Sciences on October, 2009 by the United States Patent and Trademark Office.

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Patent attributes

Current Assignee

454 Life Sciences

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Brian C. Godwin0

Michael Egholm0

Stephen Kyle Hutchison0

Zhoutao Chen0

Gary James Sarkis0

Jan Berka0

Jan Fredrik Simons0

John Harris Leamon0

Date of Patent

October 13, 2009

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Patent Application Number

114484620

Date Filed

June 6, 2006

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Patent Citations Received

US Patent 12006544 Safe sequencing system

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US Patent 12087401 Using cell-free DNA fragment size to detect tumor-associated variant

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US Patent 11705217 Sequencing using concatemers of copies of sense and antisense strands

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Patent Primary Examiner

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Patent abstract

The present invention provides for a method of preparing a target nucleic acid fragments to produce a smaller nucleic acid which comprises the two ends of the target nucleic acid. Specifically, the invention provides cloning and DNA manipulation strategies to isolate the two ends of a large target nucleic acid into a single small DNA construct for rapid cloning, sequencing, or amplification.

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