US Patent 7595374 Heparin binding motif and use thereof

Patent 7595374 was granted and assigned to National Tsing Hua University on September, 2009 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

National Tsing Hua University

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7595374

Date of Patent

September 29, 2009

Patent Application Number

12125008

Date Filed

May 21, 2008

Patent Primary Examiner

‌

Prema Mertz

Patent abstract

A method for reducing cytotoxicity of eosinophil derived toxins comprising administering to a subject an effective amount of heparin, heparan sulfate, a potent heparanase inhibitor or a polypeptide which has sequence as follows: BZBXBX, XBBBXXBX, XBBXBX, BBXXBBBXXBB, BXBBXB, XBBBXXBBBXXBBX, or TXXBXXTBXXXTBB, wherein X represents any amino acid, Z represents an aromatic amino acid, and B represents a basic amino acid and T represents a turn.