Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Alex Burgin0
John W. Walchli0
Kathryn Hjerrild0
Lansing J. Stewart0
Date of Patent
September 8, 2009
Patent Application Number
11338861
Date Filed
January 24, 2006
Patent Primary Examiner
Patent abstract
Pieces of software and databases are used to facilitate the design and synthesis of genes. The synthesis techniques allow identification, quantification, transcription, translation, and manipulation of portions of the gene sequence represented as 0's and 1's in a computing system. These pieces of software and databases compile constraint information provided by a user to create synthetic genes to express proteins lacking disordered or variable regions and containing surface mutations that promote solubility and/or crystallization. Regions of the gene sequence that do not form stable structures can be removed and replaced by a short biological linker to improve crystallization of proteins.
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