Patent 7582758 was granted and assigned to METABASIS THERAPEUTICS, INC. on September, 2009 by the United States Patent and Trademark Office.
Methods for the synthesis of cyclic phosphonic acid diesters from 1,3-diols are described, whereby cyclic phosphonic acid diesters are produced by reacting a chiral 1,3-diol and an activated phosphonic acid in the presence of a Lewis acid.