US Patent 7569219 Recombinant double-stranded RNA phage, and use of the same

Patent 7569219 was granted and assigned to University of Maryland Biotechnology Institute on August, 2009 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

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University of Maryland Biotechnology Institute

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7569219

Patent Inventor Names

David Hone0

Date of Patent

August 4, 2009

Patent Application Number

11361007

Date Filed

February 24, 2006

Patent Primary Examiner

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Christopher S. F. Low

Patent abstract

A recombinant double stranded RNA (dsRNA) phage expresses dsRNA-encoded genes in eukaryote cells. Recombinant dsRNA phage are useful for the expression of dsRNA expression cassettes encoding passenger genes, such as, but not restricted to, vaccine antigens, bioactive proteins, immunoregulatory proteins, antisense RNAs, and catalytic RNAs in eukaryotic cells or tissues. Methods are provided to deliver recombinant dsRNA phage to eukaryotic cells and tissues, either by direct administration, formulated in lipid or polylactide-coglycolide, or by utilizing a bacterial vaccine vector.