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US Patent 7566792 Method for the manufacture of Lovastatin

Patent 7566792 was granted and assigned to Lupin Limited on July, 2009 by the United States Patent and Trademark Office.

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Bhupendra Harishchandra Thakur0

Subhash Rajaram Kadam0

Sanjay Kumar Vaishnav0

Date of Patent

July 28, 2009

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Patent Application Number

105711920

Date Filed

October 14, 2003

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Patent Primary Examiner

D. Margaret Seaman

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Patent abstract

A method for the manufacture of Lovastatin of formula (I) is disclosed. The method comprises of: A. lactonisation of Mevinolinic acid (II) and isolation of impure Lovastatin (I), B. purification of impure Lovastatin (I), C. optionally, repurification of pure Lovastatin (I) from a mixture of alumina and a water miscible solvent.

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