US Patent 7563601 Artificial riboswitch for controlling pre-mRNA splicing

Patent 7563601 was granted and assigned to City of Hope on July, 2009 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

City of Hope

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7563601

Date of Patent

July 21, 2009

Patent Application Number

11446527

Date Filed

June 1, 2006

Patent Citations Received

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US Patent 11702646 Methods for modulating RNA splicing

Patent Primary Examiner

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Jane Zara

Patent abstract

The present invention relates to riboswitches that have been engineered to regulate pre-mRNA splicing. In particular, the insertion of a high affinity theophylline binding aptamer into the 3′ splice site region, 5′ splice site region, or branchpoint sequence (BPS) of a pre-mRNA modulates RNA splicing in the presence of theophylline. Accordingly, the aspects of the present invention include, but are not limited to, theophylline-dependent riboswitches which modulate RNA splicing, methods of modulating RNA splicing using theophylline and its corresponding riboswitches, methods of improving/identifying theophylline-dependent riboswitches, methods of treating diseases associated with or caused by abnormal RNA splicing.