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US Patent 7544784 Increased recovery of active proteins

Patent 7544784 was granted and assigned to Immunex on June, 2009 by the United States Patent and Trademark Office.

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Patent
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Patent attributes

Current Assignee
Immunex
Immunex
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
75447840
Patent Inventor Names
Helmut M. Sassenfeld0
Rebecca E. McCoy0
Richard L. Remmele, Jr.0
Date of Patent
June 9, 2009
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Patent Application Number
116035440
Date Filed
November 22, 2006
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Patent Citations Received
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US Patent 12110312 Integrated continuous manufacturing of therapeutic protein drug substances
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US Patent 11839861 Sterile chromatography resin and use thereof in manufacturing processes
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US Patent 11912739 Sterile chromatography and manufacturing processes
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Patent Primary Examiner
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Prema Mertz
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Patent abstract

The invention provides methods of increasing yields of desired conformation of proteins. In particular embodiments, the invention includes contacting preparations of a recombinant protein with a reduction/oxidation coupling reagent for a time sufficient to increase the relative proportion of a desired configurational isomer.

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