Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
David Knott0
Trine Jepsen0
Bjarne Due Larsen0
Carsten Boye Knudsen0
Kirsten Ebbehøj0
Date of Patent
June 9, 2009
0Patent Application Number
105298580
Date Filed
October 2, 2003
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention disclosed compositions comprising a stabilized Exendin-4 (1-39) and related compounds. The invention describes stabilized Exendin-4 agonists that include at least one modified amino acid residue particularly at positions Gln 13, Met14, Trp25, or Asn28 of the Exendin-4 (1-39) molecule. Disclosed are preferred modifications of deaminated, hydrolyzed, oxidized, or isomerized reaction products of the specified amino acid residues corresponding to the same positions in the Exendin-4 molecule. The invention also relates to methods of making and using the stabilized Exendin compounds, such as for the treatment of diabetes.
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