Is a
Patent attributes
Current Assignee
Patent Jurisdiction
Patent Number
Patent Inventor Names
Cathy Ann-Rusmussen Ivarie0
Paul Barth Conrad0
Lynn Allen-Hoffmann0
Date of Patent
June 2, 2009
0Patent Application Number
110060140
Date Filed
December 7, 2004
0Patent Citations Received
Patent Primary Examiner
Patent abstract
The present invention relates to in vitro cultured skin substitutes, and in particular to improved methods for organotypic culture of skin substitutes. In some embodiments, the dermal equivalent of the skin substitute is lifted to air interface of the culture prior to seeding with keratinocytes. In other embodiments, increased concentrations of collagen are used to form the dermal equivalent. In still other embodiments, optimized media are utilized to maintain the skin equivalents.
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