Is a
Patent attributes
Patent Jurisdiction
Patent Number
Date of Patent
April 28, 2009
Patent Application Number
10495146
Date Filed
November 11, 2002
Patent Primary Examiner
Patent abstract
The invention relates to the modification of antibodies reactive to human tumor necrosis factor alpha (TNF alpha) to result in anti-TNF alpha antibodies that are substantially non-immunogenic or less immunogenic than any non-modified parental antibody when used in vivo. The invention relates also to peptide molecules comprising T-cell epitopes of the V-regions of the parental antibody which are modified by amino acid alteration in order to reduce or eliminate said T-cell epitopes.
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