US Patent 7514406 Methods for inhibiting deacetylase activity

Patent 7514406 was granted and assigned to Fred Hutchinson Cancer Research Center on April, 2009 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Fred Hutchinson Cancer Research Center

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7514406

Date of Patent

April 7, 2009

Patent Application Number

10496031

Date Filed

November 26, 2002

Patent Primary Examiner

‌

Brandon J Fetterolf

Patent abstract

A method for identifying a compound that inhibits the NAD+-dependent deacetylase activity of a SIR2 protein is disclosed. These compounds are useful for the treatment of cancers and other diseases, through the activation of silenced genes, through the promotion of apoptosis in cancerous cells, and through the inhibition of transcriptional repressor activity in oncogenes.