Patent 7495103 was granted and assigned to Vertex Pharmaceuticals on February, 2009 by the United States Patent and Trademark Office.
The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.