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US Patent 7495099 High-molecular weight derivatives of camptothecins

Patent 7495099 was granted and assigned to Nippon Kayaku on February, 2009 by the United States Patent and Trademark Office.

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Patent
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Patent attributes

Current Assignee
Nippon Kayaku
Nippon Kayaku
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
74950990
Patent Inventor Names
Masayuki Kitagawa0
Kazuya Okamoto0
Date of Patent
February 24, 2009
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Patent Application Number
105326700
Date Filed
October 29, 2003
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Patent Primary Examiner
‌
Charanjit S. Aulakh
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Patent abstract

It is intended to provide water-soluble derivative of camptothecins which are excellent in therapeutic effect and suitable for chemotherapy for cancer. Namely, a water-soluble high-molecular weight derivative of camptothencins being excellent in sustained-release which is obtained by ester-bonding a carboxylic acid group of a polyethylene glycol-polycarboxylic acid polymer to a phenolic hydroxyl group of phenolic camptothencins.

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