Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Julia Romanova0
Boris Ferko0
Dietmar Katinger0
Hermann Katinger0
Andre Egorov0
Date of Patent
February 24, 2009
0Patent Application Number
103815300
Date Filed
September 25, 2001
0Patent Primary Examiner
Patent abstract
The invention relates to a simple and efficient process for isolating viruses from various sources and for producing live attenuated influenza vaccines in a serum-free Vero cell culture under conditions where alterations in the surface antigens of the virus due to adpative selection are minimized or prevented. The process does not require purification of the virus-containing supernatant harvested from the cell culture nor post-incubation treatment of the viruses for HA activation. The invention further relates to influenza A and B master strain candidates and to vaccines made thereof.
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