US Patent 7488466 Preparation for determining pyrimidine metabolic capacity

Patent 7488466 was granted and assigned to Otsuka Pharmaceutical on February, 2009 by the United States Patent and Trademark Office.

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Is a

Patent

Patent attributes

Current Assignee

Otsuka Pharmaceutical

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

7488466

Date of Patent

February 10, 2009

Patent Application Number

10208851

Date Filed

August 1, 2002

Patent Primary Examiner

‌

D. L. Jones

Patent abstract

The present invention provide a method for measuring and assessing the capacity in an individual subject to metabolize a variety of fluorouracil drugs, such as 5-fluorouracil, which are degraded in the pyrimidine metabolic pathway, and a preparation useful for the measurement and assessment. The present invention can be carried out by: administering a preparation for determining pyrimidine metabolic capacity comprising as an active ingredient a pyrimidine compound or pyrimidine metabolic compound that acts as a substrate for a pyrimidine metabolizing enzyme, in which at least one of the carbon, oxygen, and nitrogen atoms is labeled with an isotope; and assessing in vivo pyrimidine metabolic capacity based on the behavior of an excreted metabolite.