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US Patent 7485726 Process for the preparation of risedronate sodium hemi-pentahydrate

Patent 7485726 was granted and assigned to Aurobindo Pharma on February, 2009 by the United States Patent and Trademark Office.

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Patent abstract

The present invention relates to an improved process for the selective crystallization of 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid sodium in pure hemi-pentahydrate form of Formula (I), by first converting 3-pyridyl-1-hydroxyethylidene-1,1-bisphosphonic acid into organic amine salt and then by replacing it with sodium salt.

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