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US Patent 7485295 Compositions and methods of using chondroitinase ABCI mutants

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Patent Jurisdiction

United States Patent and Trademark Office

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Patent Number

Patent Inventor Names

Jennifer Iaci0

Andrea Vecchione0

Anthony O. Caggiano0

Elizabeth Markensohn0

Date of Patent

February 3, 2009

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Patent Application Number

115273180

Date Filed

September 26, 2006

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Patent Primary Examiner

Rebecca E. Prouty

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Patent abstract

One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using chondroitinase ABCI mutant enzymes are also provided.

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