Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Sukanto Sinha0
Guriqbal Basi0
John Anderson0
Lisa McConlogue0
Date of Patent
January 27, 2009
0Patent Application Number
108370210
Date Filed
April 30, 2004
0Patent Primary Examiner
Patent abstract
Human BACE polypeptides having modifications to the N-linked glycosylation sites including one or more of the following amino acid substitutions: S174I, N223A, N153Q and N354S. DNA sequences, vectors, and host cells for producing the polypeptides. Crystalline protein compositions formed from the purified polypeptides. Methods of screening for compounds that inhibit Aβ using the polypeptides.
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