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US Patent 7473421 Humanized anti-CCR2 antibodies and methods of use therefor

Patent 7473421 was granted and assigned to Millennium Pharmaceuticals on January, 2009 by the United States Patent and Trademark Office.

Overview Structured Data Issues Contributors Activity

Is a

Patent

Patent attributes

Current Assignee

Millennium Pharmaceuticals

Patent Jurisdiction

United States Patent and Trademark Office

Patent Number

74734211

Patent Inventor Names

Walter Newman1

S. Tarran Jones1

Siobhan H. O'Brien1

Theresa O'Keefe1

Christopher Horvath1

Gregory J. LaRosa1

Date of Patent

January 6, 2009

Patent Application Number

107667731

Date Filed

January 27, 2004

Patent Primary Examiner

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Bruce Campell

Patent abstract

The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor 2 (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to use of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.