The vehicle body structure is suitable for use in two-door automobiles. The strength of a rearward part of the vehicle body is increased to reliably suppress the deformation of the vehicle body in a possible collision from behind the vehicle. The vehicle body structure includes: a rear wheel house arranged to the rear of a center pillar; and a reinforcement member directly connecting a front part in front of the top portion of the rear wheel house with the center pillar, the front part being inclusive of the top portion of the rear wheel house.