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US Patent 7465714 Oligonucleotide inhibitors of MBD2/DNA demethylase and uses thereof

Patent 7465714 was granted and assigned to McGill on December, 2008 by the United States Patent and Trademark Office.

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Patent
Patent
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Patent attributes

Current Assignee
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McGill
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Patent Jurisdiction
United States Patent and Trademark Office
United States Patent and Trademark Office
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Patent Number
74657140
Patent Inventor Names
Paul Campbell0
Moshe Szyf0
Date of Patent
December 16, 2008
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Patent Application Number
105184700
Date Filed
June 20, 2003
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Patent Primary Examiner
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J. E. Angell
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Patent abstract

Oligonucleotide inhibitors that inhibit expression of a mammalian MBD2/DNA demethylase (MBD2/dMTase) are provided. The oligonucleotide inhibitors can be used to inhibit the growth or proliferation of tumor cells in vitro and in vivo. The use of the oligonucleotide inhibitors in the treatment of cancer and methods of identifying potential target genes for cancer therapy or diagnosis using the oligonucleotide inhibitors are also provided.

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