Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Hans-Dieter Jakubke0
Frank Bordusa0
Date of Patent
December 2, 2008
Patent Application Number
10398493
Date Filed
October 5, 2001
Patent Primary Examiner
Patent abstract
The method for producing peptides, peptide mimetics and proteins is characterized in that an enzyme is used as a biocatalyst together with a peptide mimetic. The native specificity of the enzyme is modified by chemical or genetic manipulation, the substrate mimetic is a carboxyl component with an ester leaving group whose specificity determinant is adapted to the recognition site of the enzyme. The invention also concerns the trypsin variant D189K,K60E and its use as a C-N ligase in segment condensations.
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