Is a
Patent attributes
Patent Jurisdiction
Patent Number
Patent Inventor Names
Marie Kosco-Vilbois0
Tracy Handel0
Amanda Proudfoot0
Date of Patent
September 16, 2008
Patent Application Number
10510658
Date Filed
April 9, 2003
Patent Primary Examiner
Patent abstract
Novel antagonists of MCP proteins, in particular of MCP-1 protein, can be obtained by generating MCP mutants whose GAG binding site, located at the N-terminal of MCP proteins, is eliminated following non-conservative substitutions. Compounds prepared in accordance with the present invention can be used in the treatment or prevention of diseases related to an undesirable activity of MCP proteins such, such as inflammatory disease, autoimmune diseases, vascular diseases, and cancer.
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